Publications

2020

Glioma escape signature and clonal development under immune pressure.
Maire CL, Mohme M, Bockmayr M, Fita KD, Riecken K, Börnigen D, Alawi M, Failla AV, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K. J Clin Invest. 2020 Jun 30:138760. doi: 10.1172/JCI138760. PMID: 32603315

Genomic characterization of vulvar squamous cell carcinoma. Prieske K, Alawi M, Oliveira-Ferrer L, Jaeger A, Eylmann K, Burandt E, Schmalfeldt B, Joosse SA, Woelber L. Gynecol Oncol. 2020 Jun 24:S0090-8258(20)32297-6. doi: 10.1016/j.ygyno.2020.06.482. PMID: 32591094

Draft Genome Sequence of the Green Alga Scenedesmus acuminatus SAG 38.81. Astafyeva Y, Alawi M, Indenbirken D, Danso D, Grundhoff A, Hanelt D, Streit WR, Krohn I. Microbiol Resour Announc. 2020 Jun 11;9(24):e01278-19. doi: 10.1128/MRA.01278-19. PMID: 32527781

Exome sequencing in 38 patients with intracranial aneurysms and subarachnoid hemorrhage. Sauvigny T, Alawi M, Krause L, Renner S, Spohn M, Busch A, Kolbe V, Altmüller J, Löscher BS, Franke A, Brockmann C, Lieb W, Westphal M, Schmidt NO, Regelsberger J, Rosenberger G. J Neurol. 2020 May 4. doi: 10.1007/s00415-020-09865-6. PMID: 32367296

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. Thiele S, Stanelle-Bertram S, Beck S, Kouassi NM, Zickler M, Müller M, Tuku B, Resa-Infante P, van Riel D, Alawi M, Günther T, Rother F, Hügel S, Reimering S, McHardy A, Grundhoff A, Brune W, Osterhaus A, Bader M, Hartmann E, Gabriel G. Cell Rep. 2020 Apr 21;31(3):107549. doi: 10.1016/j.celrep.2020.107549. PMID: 32320654

A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice. Zazara DE, Wegmann M, Giannou AD, Hierweger AM, Alawi M, Thiele K, Huber S, Pincus M, Muntau AC, Solano ME, Arck PC. J Allergy Clin Immunol. 2020 Apr 9. pii: S0091-6749(20)30335-3. doi: 10.1016/j.jaci.2020.01.050. PMID: 32305348

Influence of anti-thymocyte globulin plasma levels on outcome parameters in stem cell transplanted children. Vogelsang V, Kruchen A, Wustrau K, Spohn M, Müller I. Int Immunopharmacol. 2020 Mar 17;83:106371. doi: 10.1016/j.intimp.2020.106371. PMID: 32197227

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape. Mohme M, Maire CL, Schliffke S, Joosse SA, Alawi M, Matschke J, Schüller U, Dierlamm J, Martens T, Pantel K, Riethdorf S, Lamszus K, Westphal M. Acta Neuropathol Commun. 2020 Mar 9;8(1):28. doi: 10.1186/s40478-020-00906-9. PMID: 32151286

Clonal evolution after allogeneic stem cell transplantation: the case of myelofibrosis. Christopeit M, Badbaran A, Alawi M, Flach J, Fehse B, Kröger N. Biol Blood Marrow Transplant. 2020 Mar 5. pii: S1083-8791(20)30107-5. doi: 10.1016/j.bbmt.2020.02.021. PMID: 32147533

Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H; PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P; PCAWG Consortium. The landscape of viral associations in human cancers. Nat Genet. 2020 Feb 5. doi: 10.1038/s41588-019-0558-9. PMID: 32025001

ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. PMID: 32025007

Horváth A, Christ T, Koivumäki JT, Prondzynski M, Zech ATL, Spohn M, Saleem U, Mannhardt I, Ulmer B, Girdauskas E, Meyer C, Hansen A, Eschenhagen T, Lemoine MD. Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca). Cells. 2020 Jan 20;9(1). pii: E253. doi: 10.3390/cells9010253. PMID: 31968557

2019

Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, Peters F, Immenschuh J, Hellwig M, Niesen J, Mall V, Ertl-Wagner B, Hagel C, Spohn M, Lutz B, Sedlacik J, Indenbirken D, Merk DJ, Schüller U. The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration. Acta Neuropathol Commun. 2019 Dec 5;7(1):199. doi: 10.1186/s40478-019-0849-5. PMID: 31806049

Zur Stadt U, Alawi M, Adao M, Indenbirken D, Escherich G, Horstmann MA. Characterization of novel, recurrent genomic rearrangements as sensitive MRD targets in childhood B-cell precursor ALL. Blood Cancer J. 2019 Nov 29;9(12):96. doi: 10.1038/s41408-019-0257-x. PMID: 31784504

Alawi M, Burkhardt L, Indenbirken D, Reumann K, Christopeit M, Kröger N, Lütgehetmann M, Aepfelbacher M, Fischer N, Grundhoff A. DAMIAN: an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples. Sci Rep. 2019 Nov 14;9(1):16841. doi: 10.1038/s41598-019-52881-4. PMID: 31727957

Prondzynski M, Lemoine MD, Zech AT, Horváth A, Di Mauro V, Koivumäki JT, Kresin N, Busch J, Krause T, Krämer E, Schlossarek S, Spohn M, Friedrich FW, Münch J, Laufer SD, Redwood C, Volk AE, Hansen A, Mearini G, Catalucci D, Meyer C, Christ T, Patten M, Eschenhagen T, Carrier L. Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy. EMBO Mol Med. 2019 Nov 3:e11115. doi: 10.15252/emmm.201911115. PMID: 31680489

Spieck E, Spohn M, Wendt K, Bock E, Shively J, Frank J, Indenbirken D, Alawi M, Lücker S, Hüpeden J. Extremophilic nitrite-oxidizing Chloroflexi from Yellowstone hot springs. ISME J. 2019 Oct 17. doi: 10.1038/s41396-019-0530-9. PMID: 31624340

Simnica D, Schliffke S, Schultheiß C, Bonzanni N, Fanchi LF, Akyüz N, Gösch B, Casar C, Thiele B, Schlüter J, Lohse AW, Binder M. High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias. Front Immunol. 2019 Aug 21;10:1897. doi: 10.3389/fimmu.2019.01897. eCollection 2019. PMID: 31497012

Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 Aug 19. doi: 10.1038/s41587-019-0227-7. PMID: 31427818

Karaca E, Posey JE, Bostwick B, Liu P, Gezdirici A, Yesil G, Coban Akdemir Z, Bayram Y, Harms FL, Meinecke P, Alawi M, Bacino CA, Sutton VR, Kortüm F, Lupski JR. Biallelic and De Novo Variants in DONSON Reveal a Clinical Spectrum of Cell Cycle-opathies with Microcephaly, Dwarfism and Skeletal Abnormalities. Am J Med Genet A. 2019 Aug 13. doi: 10.1002/ajmg.a.61315. PMID: 31407851

Schmidt T, Schmidt C, Strahl A, Mussawy H, Rolvien T, Jandl NM, Casar C, Oheim R, Schinke T, Lohse AW, Amling M, Schramm C, Barvencik F. A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2019 Jun 1. pii: S1542-3565(19)30593-2. doi: 10.1016/j.cgh.2019.05.043. PMID:31163277

Resa‐Infante, P. , Bonet, J. , Thiele, S. , Alawi, M. , Stanelle‐Bertram, S. , Tuku, B. , Beck, S. , Oliva, B. and Gabriel, G. Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin‐α7 mediated nuclear import pathway. FEBS J. 2019 May 1. doi:10.1111/febs.14868. PMID: 31044563

Hellwig M, Lauffer MC, Bockmayr M, Spohn M, Merk DJ, Harrison L, Ahlfeld J, Kitowski A, Neumann JE, Ohli J, Holdhof D, Niesen J, Schoof M, Kool M, Kraus C, Zweier C, Holmberg D, Schüller U. TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma. Acta Neuropathol. 2019 Apr 1. doi: 10.1007/s00401-019-01982-5. PubMed PMID: 30830316

Renner S, Schüler H, Alawi M, Kolbe V, Rybczynski M, Woitschach R, Sheikhzadeh S, Stark VC, Olfe J, Roser E, Seggewies FS, Mahlmann A, Hempel M, Hartmann MJ, Hillebrand M, Wieczorek D, Volk AE, Kloth K, Koch-Hogrebe M, Abou Jamra R, Mitter D, Altmüller J, Wey-Fabrizius A, Petersen C, Rau I, Borck G, Kubisch C, Mir TS, von Kodolitsch Y, Kutsche K, Rosenberger G. Next-generation sequencing of 32 genes associated with hereditary aortopathies and related disorders of connective tissue in a cohort of 199 patients. Genet Med. 2019 Jan 24. doi: 10.1038/s41436-019-0435-z. PubMed PMID: 30675029

Seoane M, Buhs S, Iglesias P, Strauss J, Puller AC, Müller J, Gerull H, Feldhaus S, Alawi M, Brandner JM, Eggert D, Du J, Thomale J, Wild PJ, Zimmermann M, Sternsdorf T, Schumacher U, Nollau P, Fisher DE, Horstmann MA. Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair. Oncogene. 2019 Jan 16. doi: 10.1038/s41388-018-0661-x. PubMed PMID: 30651597.

2018

Neelagandan N, Gonnella G, Dang S, Janiesch PC, Miller KK, Küchler K, Marques RF, Indenbirken D, Alawi M, Grundhoff A, Kurtz S, Duncan KE. TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease. Nucleic Acids Res. 2018 Oct 24. doi: 10.1093/nar/gky972. PubMed PMID: 30357366.

Guo L, Huang J, Chen M, Piotrowski E, Song N, Zahner G, Paust HJ, Alawi M, Geffers R, Thaiss F. T-lymphocyte-specific knockout of IKK-2 or NEMO induces Th17 cells in an experimental nephrotoxic nephritis mouse model. FASEB J. 2018 Oct 4:fj201800485RR. doi: 10.1096/fj.201800485RR. PubMed PMID: 30285578.

Harms FL, Nampoothiri S, Kortüm F, Thomas J, Panicker VV, Alawi M, Altmüller J, Yesodharan D, Kutsche K. Coinheritance of biallelic SLURP1 and SLC39A4 mutations cause a severe genodermatosis with skin peeling and hair loss all over the body. Br J Dermatol. 2018 Jun 27. doi: 10.1111/bjd.16912. PubMed PMID: 29947416.

Piard J, Essien Umanah GK, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, Van Maldergem L, Kutsche K. Reply: ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation. Brain. 2018 Apr 12. doi: 10.1093/brain/awy100. PubMed PMID: 29659731.

Kortüm F, Jamra RA, Alawi M, Berry SA, Borck G, Helbig KL, Tang S, Huhle D, Korenke GC, Hebbar M, Shukla A, Girisha KM, Steinlin M, Waldmeier-Wilhelm S, Montomoli M, Guerrini R, Lemke JR, Kutsche K. Clinical and genetic spectrum of AMPD2-related pontocerebellar hypoplasia type 9. Eur J Hum Genet. 2018 Feb 20. doi: 10.1038/s41431-018-0098-2. PubMed PMID: 29463858.

Harms FL, Alawi M, Amor DJ, Tan TY, Cuturilo G, Lissewski C, Brinkmann J, Schanze D, Kutsche K, Zenker M. The novel RAF1 mutation p.(Gly361Ala) located outside the kinase domain of the CR3 region in two patients with Noonan syndrome, including one with a rare brain tumor. Am J Med Genet A. 2018 Feb;176(2):470-476. doi: 10.1002/ajmg.a.38569. Epub 2017 Dec 22. PubMed PMID: 29271604.

Harms FL, Nampoothiri S, Anazi S, Yesodharan D, Alawi M, Kutsche K, Alkuraya FS. Elsahy-Waters syndrome is caused by biallelic mutations in CDH11. Am J Med Genet A. 2018 Feb;176(2):477-482. doi: 10.1002/ajmg.a.38568. Epub 2017 Dec 22. PubMed PMID: 29271567.

Piard J, Umanah GKE, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, Van Maldergem L, Kutsche K. A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy. Brain. 2018 Jan 30. doi: 10.1093/brain/awx377. PubMed PMID: 29390050; PubMed Central PMCID: PMC5837721.

2017

Krohn-Molt I, Alawi M, Förstner KU, Wiegandt A, Burkhardt L, Indenbirken D, Thieß M, Grundhoff A, Kehr J, Tholey A, Streit WR. Insights into Microalga and Bacteria Interactions of Selected Phycosphere Biofilms Using Metagenomic, Transcriptomic, and Proteomic Approaches. Front Microbiol. 2017 Oct 10;8:1941. doi: 10.3389/fmicb.2017.01941. eCollection 2017. PubMed PMID: 29067007; PubMed Central PMCID: PMC5641341.

Oberle A, Brandt A, Alawi M, Langebrake C, Janjetovic S, Wolschke C, Schütze K, Bannas P, Kröger N, Koch-Nolte F, Bokemeyer C, Binder M. Long-term CD38 saturation by daratumumab interferes with diagnostic myeloma cell detection. Haematologica. 2017 Sep;102(9):e368-e370. doi: 10.3324/haematol.2017.169235. Epub 2017 May 18. PubMed PMID: 28522580; PubMed Central PMCID: PMC5685239.

Körbelin J, Hunger A, Alawi M, Sieber T, Binder M, Trepel M. Optimization of design and production strategies for novel adeno-associated viral display peptide libraries. Gene Ther. 2017 Aug;24(8):470-481. doi: 10.1038/gt.2017.51. Epub 2017 Jul 13. PubMed PMID: 28622288.

Günther T, Haas L, Alawi M, Wohlsein P, Marks J, Grundhoff A, Becher P, Fischer N. Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample. Sci Rep. 2017 Jun 16;7(1):3734. doi: 10.1038/s41598-017-03997-y. PubMed PMID: 28623312; PubMed Central PMCID: PMC5473882.

Oberle A, Brandt A, Voigtlaender M, Thiele B, Radloff J, Schulenkorf A, Alawi M, Akyüz N, März M, Ford CT, Krohn-Grimberghe A, Binder M. Monitoring multiple myeloma by next-generation sequencing of V(D)J rearrangements from circulating myeloma cells and cell-free myeloma DNA. Haematologica. 2017 Jun;102(6):1105-1111. doi: 10.3324/haematol.2016.161414. Epub 2017 Feb 9. PubMed PMID: 28183851; PubMed Central PMCID: PMC5451343.

Nagarajan S, Bedi U, Budida A, Hamdan FH, Mishra VK, Najafova Z, Xie W, Alawi M, Indenbirken D, Knapp S, Chiang CM, Grundhoff A, Kari V, Scheel CH, Wegwitz F, Johnsen SA. BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells. Nucleic Acids Res. 2017 Apr 7;45(6):3130-3145. doi: 10.1093/nar/gkw1276. PubMed PMID: 27980063; PubMed Central PMCID: PMC5389510.

Engels G, Hierweger AM, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker HW, Arck PC, Gabriel G. Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. Cell Host Microbe. 2017 Mar 8;21(3):321-333. doi: 10.1016/j.chom.2017.02.020. PubMed PMID: 28279344.

Coronado L, Liniger M, Muñoz-González S, Postel A, Pérez LJ, Pérez-Simó M, Perera CL, Frías-Lepoureau MT, Rosell R, Grundhoff A, Indenbirken D, Alawi M, Fischer N, Becher P, Ruggli N, Ganges L. Novel poly-uridine insertion in the 3’UTR and E2 amino acid substitutions in a low virulent classical swine fever virus. Vet Microbiol. 2017 Mar;201:103-112. doi: 10.1016/j.vetmic.2017.01.013. Epub 2017 Jan 17. PubMed PMID: 28284595.

Rossi A, Voigtlaender M, Janjetovic S, Thiele B, Alawi M, März M, Brandt A, Hansen T, Radloff J, Schön G, Hegenbart U, Schönland S, Langer C, Bokemeyer C, Binder M. Mutational landscape reflects the biological continuum of plasma cell dyscrasias. Blood Cancer J. 2017 Feb 24;7(2):e537. doi: 10.1038/bcj.2017.19. PubMed PMID: 28234344; PubMed Central PMCID: PMC5386334.

2016

Harms FL, Girisha KM, Hardigan AA, Kortüm F, Shukla A, Alawi M, Dalal A, Brady L, Tarnopolsky M, Bird LM, Ceulemans S, Bebin M, Bowling KM, Hiatt SM, Lose EJ, Primiano M, Chung WK, Juusola J, Akdemir ZC, Bainbridge M, Charng WL, Drummond-Borg M, Eldomery MK, El-Hattab AW, Saleh MAM, Bézieau S, Cogné B, Isidor B, Küry S, Lupski JR, Myers RM, Cooper GM, Kutsche K. Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism. Am J Hum Genet. 2017 Jan 5;100(1):117-127. doi: 10.1016/j.ajhg.2016.11.012. Epub 2016 Dec 22. PubMed PMID: 28017373; PubMed Central PMCID: PMC5223027.

Kortüm F, Marquardt I, Alawi M, Korenke GC, Spranger S, Meinecke P, Kutsche K. Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. Pediatrics. 2017 Jan;139(1). pii: e20160550. doi: 10.1542/peds.2016-0550. PubMed PMID: 28031453.

Shashi V, Pena LD, Kim K, Burton B, Hempel M, Schoch K, Walkiewicz M, McLaughlin HM, Cho M, Stong N, Hickey SE, Shuss CM; Undiagnosed Diseases Network, Freemark MS, Bellet JS, Keels MA, Bonner MJ, El-Dairi M, Butler M, Kranz PG, Stumpel CT, Klinkenberg S, Oberndorff K, Alawi M, Santer R, Petrovski S, Kuismin O, Korpi-Heikkilä S, Pietilainen O, Aarno P, Kurki MI, Hoischen A, Need AC, Goldstein DB, Kortüm F. De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype. Am J Hum Genet. 2016 Oct 6;99(4):991-999. doi: 10.1016/j.ajhg.2016.08.017. Epub 2016 Sep 29. Erratum in: Am J Hum Genet. 2017 Jan 5;100(1):179. PubMed PMID: 27693232; PubMed Central PMCID: PMC5065681.

Schaeffer CR, Hoang TN, Sudbeck CM, Alawi M, Tolo IE, Robinson DA, Horswill AR, Rohde H, Fey PD. Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress. mSphere. 2016 Oct 5;1(5). pii: e00165-16. eCollection 2016 Sep-Oct. PubMed PMID: 27747298; PubMed Central PMCID: PMC5064449.

Fischer S, Cornils K, Speiseder T, Badbaran A, Reimer R, Indenbirken D, Grundhoff A, Brunswig-Spickenheier B, Alawi M, Lange C. Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles. PLoS One. 2016 Sep 29;11(9):e0163665. doi: 10.1371/journal.pone.0163665. eCollection 2016. PubMed PMID: 27684368; PubMed Central PMCID: PMC5042424.

Christopeit M, Badbaran A, Alawi M, Zabelina T, Zeck G, Wolschke C, Ayuk F, Kröger N. Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with myelodysplastic syndromes. Eur J Haematol. 2016 Sep;97(3):288-96. doi: 10.1111/ejh.12724. Epub 2016 Feb 15. PubMed PMID: 26680262.

Girisha KM, Kortüm F, Shah H, Alawi M, Dalal A, Bhavani GS, Kutsche K. A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene. Eur J Hum Genet. 2016 Aug;24(8):1206-10. doi: 10.1038/ejhg.2015.261. Epub 2015 Dec 16. PubMed PMID: 26669664; PubMed Central PMCID: PMC4970677.

Babayan A, Alawi M, Gormley M, Müller V, Wikman H, McMullin RP, Smirnov DA, Li W, Geffken M, Pantel K, Joosse SA. Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells. Oncotarget. 2016 Jul 19;8(34):56066-56080. doi: 10.18632/oncotarget.10701. eCollection 2017 Aug 22. PubMed PMID: 28915574; PubMed Central PMCID: PMC5593545.

Vogel M, Velleuer E, Schmidt-Jiménez LF, Mayatepek E, Borkhardt A, Alawi M, Kutsche K, Kortüm F. Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis. Am J Med Genet A. 2016 Jul;170(7):1813-9. doi: 10.1002/ajmg.a.37682. Epub 2016 May 4. PubMed PMID: 27144914.

Stadt UZ, Escherich G, Indenbirken D, Alawi M, Adao M, Horstmann MA. Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL. Pediatr Blood Cancer. 2016 Jul;63(7):1283-6. doi: 10.1002/pbc.25975. Epub 2016 Mar 23. PubMed PMID: 27007619.

Behrens K, Triviai I, Schwieger M, Tekin N, Alawi M, Spohn M, Indenbirken D, Ziegler M, Müller U, Alexander WS, Stocking C. Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions. Blood. 2016 Jun 30;127(26):3369-81. doi: 10.1182/blood-2015-09-668129. Epub 2016 Apr 13. PubMed PMID: 27076172.

Schieferdecker A, Oberle A, Thiele B, Hofmann F, Göthel M, Miethe S, Hust M, Braig F, Voigt M, von Pein UM, Koch-Nolte F, Haag F, Alawi M, Indenbirken D, Grundhoff A, Bokemeyer C, Bacher U, Kröger N, Binder M. A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma. Blood. 2016 Jun 23;127(25):3202-14. doi: 10.1182/blood-2015-10-676536. Epub 2016 Mar 31. PubMed PMID: 27034429.

Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M. Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. PLoS Pathog. 2016 Jun 14;12(6):e1005660. doi: 10.1371/journal.ppat.1005660. eCollection 2016 Jun. PubMed PMID: 27300509; PubMed Central PMCID: PMC4907486.

Postel A, Hansmann F, Baechlein C, Fischer N, Alawi M, Grundhoff A, Derking S, Tenhündfeld J, Pfankuche VM, Herder V, Baumgärtner W, Wendt M, Becher P. Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor. Sci Rep. 2016 Jun 13;6:27735. doi: 10.1038/srep27735. PubMed PMID: 27292119; PubMed Central PMCID: PMC4904412.

Güllert S, Fischer MA, Turaev D, Noebauer B, Ilmberger N, Wemheuer B, Alawi M, Rattei T, Daniel R, Schmitz RA, Grundhoff A, Streit WR. Deep metagenome and metatranscriptome analyses of microbial communities affiliated with an industrial biogas fermenter, a cow rumen, and elephant feces reveal major differences in carbohydrate hydrolysis strategies. Biotechnol Biofuels. 2016 Jun 7;9:121. doi: 10.1186/s13068-016-0534-x. eCollection 2016. PubMed PMID: 27279900; PubMed Central PMCID: PMC4897800.

Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries. Mol Ther. 2016 Jun;24(6):1050-1061. doi: 10.1038/mt.2016.62. Epub 2016 Mar 28. PubMed PMID: 27018516; PubMed Central PMCID: PMC4923327.

Schommartz T, Loroch S, Alawi M, Grundhoff A, Sickmann A, Brune W. Functional Dissection of an Alternatively Spliced Herpesvirus Gene by Splice Site Mutagenesis. J Virol. 2016 Apr 14;90(9):4626-4636. doi: 10.1128/JVI.02987-15. Print 2016 May. PubMed PMID: 26912612; PubMed Central PMCID: PMC4836318.

Herglotz J, Unrau L, Hauschildt F, Fischer M, Kriebitzsch N, Alawi M, Indenbirken D, Spohn M, Müller U, Ziegler M, Schuh W, Jäck HM, Stocking C. Essential control of early B-cell development by Mef2 transcription factors. Blood. 2016 Feb 4;127(5):572-81. doi: 10.1182/blood-2015-04-643270. Epub 2015 Dec 10. PubMed PMID: 26660426.

2015

Lellek H, Franke GC, Ruckert C, Wolters M, Wolschke C, Christner M, Büttner H, Alawi M, Kröger N, Rohde H. Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy. Int J Med Microbiol. 2015 Dec;305(8):902-9. doi: 10.1016/j.ijmm.2015.09.005. Epub 2015 Sep 12. PubMed PMID: 26454536.

Theiss JM, Günther T, Alawi M, Neumann F, Tessmer U, Fischer N, Grundhoff A. A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence. PLoS Pathog. 2015 Jul 28;11(7):e1004974. doi: 10.1371/journal.ppat.1004974. eCollection 2015 Jul. PubMed PMID: 26218535; PubMed Central PMCID: PMC4517807.

Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A. Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples. J Clin Microbiol. 2015 Jul;53(7):2238-50. doi: 10.1128/JCM.02495-14. Epub 2015 May 13. PubMed PMID: 25972420; PubMed Central PMCID: PMC4473199.

Baechlein C, Fischer N, Grundhoff A, Alawi M, Indenbirken D, Postel A, Baron AL, Offinger J, Becker K, Beineke A, Rehage J, Becher P. Identification of a Novel Hepacivirus in Domestic Cattle from Germany. J Virol. 2015 Jul;89(14):7007-15. doi: 10.1128/JVI.00534-15. Epub 2015 Apr 29. PubMed PMID: 25926652; PubMed Central PMCID: PMC4473572.

Kortüm F, Caputo V, Bauer CK, Stella L, Ciolfi A, Alawi M, Bocchinfuso G, Flex E, Paolacci S, Dentici ML, Grammatico P, Korenke GC, Leuzzi V, Mowat D, Nair LD, Nguyen TT, Thierry P, White SM, Dallapiccola B, Pizzuti A, Campeau PM, Tartaglia M, Kutsche K. Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome. Nat Genet. 2015 Jun;47(6):661-7. doi: 10.1038/ng.3282. Epub 2015 Apr 27. PubMed PMID: 25915598.

Braig F, März M, Schieferdecker A, Schulte A, Voigt M, Stein A, Grob T, Alawi M, Indenbirken D, Kriegs M, Engel E, Vanhoefer U, Grundhoff A, Loges S, Riecken K, Fehse B, Bokemeyer C, Binder M. Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer. Oncotarget. 2015 May 20;6(14):12035-47. PubMed PMID: 26059438; PubMed Central PMCID: PMC4494921.

van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K. Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet. 2015 Apr 2;96(4):640-50. doi: 10.1016/j.ajhg.2015.02.002. Epub 2015 Mar 12. PubMed PMID: 25772934; PubMed Central PMCID: PMC4385192.

Hirt MN, Werner T, Indenbirken D, Alawi M, Demin P, Kunze AC, Stenzig J, Starbatty J, Hansen A, Fiedler J, Thum T, Eschenhagen T. Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology. J Mol Cell Cardiol. 2015 Apr;81:1-9. doi: 10.1016/j.yjmcc.2015.01.008. Epub 2015 Jan 26. PubMed PMID: 25633833.

2014

Abdollahpour H, Alawi M, Kortüm F, Beckstette M, Seemanova E, Komárek V, Rosenberger G, Kutsche K. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome. Eur J Hum Genet. 2015 Feb;23(2):256-9. doi: 10.1038/ejhg.2014.73. Epub 2014 Apr 30. PubMed PMID: 24781758; PubMed Central PMCID: PMC4297901.

Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell. 2015 Jan 8;16(1):33-8. doi: 10.1016/j.stem.2014.11.003. Epub 2014 Nov 20. PubMed PMID: 25465116.

Ilmberger N, Güllert S, Dannenberg J, Rabausch U, Torres J, Wemheuer B, Alawi M, Poehlein A, Chow J, Turaev D, Rattei T, Schmeisser C, Salomon J, Olsen PB, Daniel R, Grundhoff A, Borchert MS, Streit WR. A comparative metagenome survey of the fecal microbiota of a breast- and a plant-fed Asian elephant reveals an unexpectedly high diversity of glycoside hydrolase family enzymes. PLoS One. 2014 Sep 10;9(9):e106707. doi: 10.1371/journal.pone.0106707. eCollection 2014. PubMed PMID: 25208077; PubMed Central PMCID: PMC4160196.

Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA. Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription. Cell Rep. 2014 Jul 24;8(2):460-9. doi: 10.1016/j.celrep.2014.06.016. Epub 2014 Jul 10. PubMed PMID: 25017071; PubMed Central PMCID: PMC4747248.

Thiele B, Kloster M, Alawi M, Indenbirken D, Trepel M, Grundhoff A, Binder M. Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma. Blood. 2014 Jun 5;123(23):3618-21. doi: 10.1182/blood-2014-02-556746. Epub 2014 Apr 21. PubMed PMID: 24753536.

2013

Krohn-Molt I, Wemheuer B, Alawi M, Poehlein A, Güllert S, Schmeisser C, Pommerening-Röser A, Grundhoff A, Daniel R, Hanelt D, Streit WR. Metagenome survey of a multispecies and alga-associated biofilm revealed key elements of bacterial-algal interactions in photobioreactors. Appl Environ Microbiol. 2013 Oct;79(20):6196-206. doi: 10.1128/AEM.01641-13. Epub 2013 Aug 2. PubMed PMID: 23913425; PubMed Central PMCID: PMC3811195.

Niebuhr B, Kriebitzsch N, Fischer M, Behrens K, Günther T, Alawi M, Bergholz U, Müller U, Roscher S, Ziegler M, Buchholz F, Grundhoff A, Stocking C. Runx1 is essential at two stages of early murine B-cell development. Blood. 2013 Jul 18;122(3):413-23. doi: 10.1182/blood-2013-01-480244. Epub 2013 May 23. PubMed PMID: 23704093.

2012

Werner S, Frey S, Riethdorf S, Schulze C, Alawi M, Kling L, Vafaizadeh V, Sauter G, Terracciano L, Schumacher U, Pantel K, Assmann V. Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer. J Biol Chem. 2013 Aug 9;288(32):22993-3008. doi: 10.1074/jbc.M113.456293. Epub 2013 Jun 29. PubMed PMID: 23814079; PubMed Central PMCID: PMC3743475.

2011

Alawi M, Kurtz S, Beckstette M. CASSys: an integrated software-system for the interactive analysis of ChIP-seq data. J Integr Bioinform. 2011 Jun 21;8(2):155. doi: 10.2390/biecoll-jib-2011-155. PubMed PMID: 21690655.